Sylvia B Smith Selected Research

citraconic acid (mesaconic acid)

1/2020	Comparison of Neuroprotective Effects of Monomethylfumarate to the Sigma 1 Receptor Ligand (+)-Pentazocine in a Murine Model of Retinitis Pigmentosa.
5/2014	Monomethylfumarate induces γ-globin expression and fetal hemoglobin production in cultured human retinal pigment epithelial (RPE) and erythroid cells, and in intact retina.

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Sylvia B Smith Research Topics

Disease

26	Ganglion Cysts (Ganglion) 01/2022 - 11/2002
12	Hyperhomocysteinemia 01/2022 - 01/2009
10	Diabetic Retinopathy (Retinopathy, Diabetic) 08/2022 - 11/2002
8	Gliosis 01/2022 - 03/2012
8	Hemochromatosis (Bronze Diabetes) 04/2014 - 10/2006
7	Neurodegenerative Diseases (Neurodegenerative Disease) 08/2022 - 09/2008
7	Retinal Diseases 01/2022 - 10/2007
7	Iron Overload 01/2018 - 05/2009
6	Glaucoma 01/2022 - 01/2010
6	Retinal Degeneration 01/2017 - 10/2006
6	Inflammation (Inflammations) 12/2016 - 04/2008
5	Macular Degeneration (Age-Related Maculopathy) 01/2022 - 02/2004
5	Infections 10/2021 - 10/2003
5	Inborn Genetic Diseases (Disease, Hereditary) 04/2014 - 09/2004
5	Neoplasms (Cancer) 01/2013 - 12/2006
4	Ischemia 01/2018 - 02/2013
3	Retinitis 07/2021 - 05/2009
3	Blindness (Hysterical Blindness) 11/2018 - 05/2009
3	Hyperglycemia 12/2017 - 03/2009
3	Optic Nerve Diseases (Optic Neuropathy) 03/2012 - 09/2004
3	Breast Neoplasms (Breast Cancer) 09/2008 - 12/2006
2	Virus Diseases (Viral Diseases) 07/2021 - 05/2010
2	Retinitis Pigmentosa (Pigmentary Retinopathy) 01/2021 - 01/2020
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2020 - 02/2013
2	Autosomal Dominant Optic Atrophy (Dominant Optic Atrophy) 01/2020 - 01/2017
2	Multiple Sclerosis 12/2019 - 12/2016
2	Methylenetetrahydrofolate reductase deficiency 01/2016 - 04/2015
2	Hyperplasia 01/2012 - 11/2009
2	Cytomegalovirus Infections (Inclusion Disease) 11/2011 - 05/2009
1	Atrophy 10/2021
1	Cytomegalovirus Retinitis 07/2021
1	Cancer Pain 12/2020
1	COVID-19 12/2020
1	Zika Virus Infection 09/2017
1	Substance-Related Disorders (Drug Abuse) 01/2017
1	Pain (Aches) 01/2017
1	Sickle Cell Anemia (Hemoglobin S Disease) 12/2016
1	Macular Edema 03/2015
1	Retinal Neovascularization 03/2015

Drug/Important Bio-Agent (IBA)

46	Retinaldehyde (Retinal)IBA 01/2022 - 02/2004
13	Proteins (Proteins, Gene)FDA Link 07/2021 - 04/2007
12	IronIBA 01/2018 - 10/2006
10	HomocysteineIBA 01/2022 - 04/2004
9	LigandsIBA 01/2021 - 04/2004
8	Pentazocine (Talwin)FDA LinkGeneric 01/2021 - 04/2004
6	Retinal Pigments (Pigments, Visual)IBA 02/2016 - 02/2004
5	CystathionineIBA 01/2022 - 01/2009
5	EnzymesIBA 01/2022 - 09/2004
5	HepcidinsIBA 01/2014 - 04/2008
4	Messenger RNA (mRNA)IBA 07/2021 - 11/2002
4	Neuroprotective AgentsIBA 01/2020 - 10/2007
3	Caspase 3 (Caspase-3)IBA 07/2021 - 09/2004
3	Glial Fibrillary Acidic ProteinIBA 01/2016 - 05/2014
3	CaspasesIBA 10/2014 - 09/2008
3	Iron-Regulatory Proteins (Iron-Responsive Element Binding Proteins)IBA 05/2014 - 05/2009
3	Folic Acid (Vitamin M)FDA LinkGeneric 03/2012 - 07/2003
3	metal transporting protein 1 (ferroportin)IBA 01/2012 - 05/2009
3	Transferrin Receptors (Transferrin Receptor)IBA 01/2012 - 05/2009
3	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 07/2011 - 11/2002
3	Glutamic Acid (Glutamate)FDA Link 03/2009 - 04/2004
2	Glucose (Dextrose)FDA LinkGeneric 08/2022 - 01/2013
2	Excitatory Amino AcidsIBA 01/2022 - 01/2019
2	citraconic acid (mesaconic acid)IBA 01/2020 - 05/2014
2	Dynamins (Dynamin)IBA 01/2020 - 01/2017
2	ArginaseIBA 12/2019 - 01/2018
2	AntioxidantsIBA 12/2017 - 03/2009
2	NADPH Oxidases (NAD(P)H oxidase)IBA 03/2015 - 03/2015
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 03/2015 - 09/2014
2	Arachidonate 15-Lipoxygenase (Arachidonate 15 Lipoxygenase)IBA 03/2015 - 03/2015
2	AntigensIBA 09/2014 - 01/2012
2	VimentinIBA 05/2014 - 11/2008
2	CholesterolIBA 04/2014 - 10/2002
2	Cystathionine beta-Synthase (Serine Sulfhydrase)IBA 02/2013 - 03/2012
2	ferric ammonium citrate FDA Link 11/2011 - 06/2011
2	Histone Deacetylases (Histone Deacetylase)IBA 04/2009 - 12/2006
2	Glutathione (Reduced Glutathione)IBA 03/2009 - 09/2004
1	dihydroethidiumIBA 01/2022
1	InterferonsIBA 07/2021
1	Caspase 12IBA 07/2021
1	Metalloproteases (Metalloproteinases)IBA 01/2020
1	ZincIBA 01/2020
1	Biomarkers (Surrogate Marker)IBA 01/2019
1	Biological ProductsIBA 11/2018
1	ReninIBA 01/2018
1	UreohydrolasesIBA 01/2018
1	N-Me-Tyr1,D-Ala2,Asn8,Arg29-NHCH3-JI-38IBA 12/2017
1	Growth Hormone-Releasing Hormone (Somatotropin Releasing Hormone)IBA 12/2017
1	Therapeutic UsesIBA 12/2017
1	Peanut AgglutininIBA 01/2017
1	Taurine FDA Link 01/2017
1	sigma Receptors (sigma Receptor)IBA 01/2017
1	monomethyl fumarateIBA 12/2016
1	Sigma-1 ReceptorIBA 02/2016
1	Mitogen-Activated Protein KinasesIBA 02/2016
1	Molecular Chaperones (Chaperone, Molecular)IBA 01/2016
1	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 01/2016
1	Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)IBA 04/2015
1	Hydroxyeicosatetraenoic Acids (HETE)IBA 03/2015
1	12-Hydroxy-5,8,10,14-eicosatetraenoic AcidIBA 03/2015

Therapy/Procedure

3	Therapeutics 12/2020 - 05/2014